Question: Why enzymes change shape at a high temperature ?

Natasha Myhill answered on 8 Nov 2017:

So this is called denaturing – enzymes are proteins, and they are made up of a chain of amino acids (primary structure), which is then pleated or spiralled (secondary structure), and then folded and held together by different bonds between particular amino acids (tertiary structure). So when the temperature becomes too high, the bonds in the tertiary structure become unstable and break (usually do to too much movement – the more you heat a molecule, the more it moves). This is why enzymes change shape and do not work properly at a high temperature.